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KMID : 0921620220520010039
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Journal of Bacteriology and Virology
2022 Volume.52 No. 1 p.39 ~ p.40
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Recombinant ACE2-Ig Fusion Protein Neutralizes SARS-CoV-2
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Song Jin-Woo
Koh Young-Sang
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Abstract
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A novel coronavirus (SARS-CoV-2) is the causative agent for the COVID-19 pandemic, and needs for effective antiviral drugs have been demanded. Angiotensin-converting enzyme 2 (ACE2) has been shown to be a cellular receptor for SARS-CoV and SARS-CoV-2. For the therapeutic validation of ACE2, a recombinant protein consisting of the ACE2 extracellular domain fused to the IgG1 Fc domain (ACE2-Ig) was generated. ACE2-Ig exhibits proper pharmacological properties and binds with a high affinity to SARS-CoV and SARS-CoV-2 receptor-binding domain. Further, it neutralizes virus with SARS-CoV and SARS-CoV-2 spike proteins. Taken overall, these data suggest that ACE2-Ig has substantial anti-SARS-CoV-2 properties and warrant further study concerning its potential applications for the treatment of SARS-CoV-2.
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KEYWORD
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SARS-CoV-2, ACE2-Ig, Neutralization, Affinity, Receptor-binding domain
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